Clinical Assessment of MitoQ on Microvascular and Mitochondrial Function

The aims of this project are to examine (1) the mitochondria as a source of oxidative stress that causes vessel dysfunction in primary aging and (2) the efficacy of MitoQ (a mitochondria-specific antioxidant) for reducing mitochondrial oxidative stress and, thereby, improving blood vessel function.

• Sponsor
  MitoQ
  $97,437

• Principal investigator
  S. Tony Wolf
  Assistant professor
  Department of Kinesiology

• Active since
  November 2024

Abstract

Aging is associated with blood vessel dysfunction that precedes the development of hypertension and cardiovascular disease. Age-related vessel dysfunction is mediated, in part, by increased oxidative stress.

The aims of this project are to examine (1) the mitochondria as a source of oxidative stress that causes vessel dysfunction in primary aging and (2) the efficacy of MitoQ (a mitochondria-specific antioxidant) for reducing mitochondrial oxidative stress and, thereby, improving blood vessel function.